Protein Details: Amiloride-sensitive sodium channel subunit beta
Protein ID
ICDB_Pro_1389
Protein Name
Amiloride-sensitive sodium channel subunit beta
Gene Name
SCNN1B
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Length
641 amino acids
AlphaFoldDB
AF-Q95165-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney; colon; lung and sweat glands. Also plays a role in taste perception.
Sequence
MHLKKYLLKGLHRLQKGPGYSYKELLVWYCNNTNTHGPKRIICEGPKKKAMWFLITLLFTSLVCWQWGVFIRTYLSWEVSVSLSLGFKTMDFPAVTICNASPFQYSKVKHLLRDLDELMEAVLERILAPEHSDANATRTLNVTMWNYTPLVLIDEQNPHCPVVLDLFGDIHNGSASSSPAPARSCTVHGCKVAMRLCSLNGTVCTFRNFTSATQAVTEWYLLQATNIFSQVPQRELVEMSYPAERLILACLFGAEPCSYRNFTSIFHPDYGNCYIFNWGMTEKALPSANPGAEFGLKLILDIGQEDYVPFLTSTAGARLMLHEQRSYPFIKDEGIYAMSGTETSIGVLVDRLERKGEPYSQCTVNGSDVPVRNLYSDYNTTYSIQACIRSCFQDHMIQNCSCAHYLYPLPRGERYCNNREFPDWAYCYSHLRMSVAQRETCINMCKESCNDTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGVVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEILIDFVWITIIKLVAFAKSLRQKRAQARYAGPPPTVAELVEAHTNFGFQPDVARPGPDPGTYPDEQTLPIPGTPPPNYDSLRLQPLDVIESDSEGDAI
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1038/nature04338
RefSeq
NP_001300793.1; XP_005621477.1